Related Experiment Video

Updated: Jan 31, 2026

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

12.0K

Overview of HCV Life Cycle with a Special Focus on Current and Possible Future Antiviral Targets

Nathalie Alazard-Dany1, Solène Denolly2, Bertrand Boson3

  • 1CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, France. nathalie.alazard-dany@inserm.fr.

Viruses
|January 10, 2019
PubMed

Insights

Hepatitis C (HCV) eradication is achievable by 2030 thanks to highly effective direct-acting antivirals (DAAs). This review covers HCV targets, DAA mechanisms, and future inhibitor development for liver disease treatment.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Hepatitis C virus (HCV) infection is a primary cause of liver disease globally, impacting approximately 3% of the population.
  • The World Health Organization (WHO) aims for HCV eradication by 2030, driven by advancements in treatment.

Purpose of the Study:

  • To provide an overview of the Hepatitis C virus life cycle.
  • To describe the functions of molecular targets for current direct-acting antivirals (DAAs).
  • To explain the mechanisms of action for existing DAAs and explore potential future inhibitors.

Main Methods:

  • Literature review of scientific publications since the 1990s.
  • Analysis of the molecular targets and mechanisms of direct-acting antivirals.
  • Discussion of research and development in antiviral therapies.

Main Results:

  • Direct-acting antivirals (DAAs) developed since the 1990s are highly effective treatments for Hepatitis C.
  • Current DAAs target specific proteins essential for the HCV life cycle.
  • Significant progress has been made, supporting the WHO's 2030 eradication goal.

Conclusions:

  • Novel DAAs represent a major breakthrough in managing and potentially eliminating Hepatitis C virus infection.
  • Understanding viral targets and drug mechanisms is crucial for developing next-generation inhibitors.
  • Continued research is vital to achieve global HCV eradication.

Keywords:
DAAHCVantiviral targets

More Related Videos

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay12:49

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay

Published on: May 25, 2015

10.5K
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.9K

Related Concept Videos

The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.4K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.6K
Controlled-Current Coulometry: Overview01:27

Controlled-Current Coulometry: Overview

Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
699
Characteristics of Life01:23

Characteristics of Life

Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
260.8K
The Citric Acid Cycle: Overview01:37

The Citric Acid Cycle: Overview

In aerobic organisms, the citric acid cycle is the second stage of cellular respiration wherein molecules derived from the breakdown of carbohydrates, proteins, and fats are oxidized into carbon dioxide and energy. This process is also known as the tricarboxylic acid (TCA) cycle as the first product of the cycle, citric acid, contains three carboxyl groups in its structure. Alternatively, this cycle is also referred to as the Krebs cycle, in honor of its discoverer Sir Hans Krebs.
The citric...
22.7K
Half-life of a Reaction02:42

Half-life of a Reaction

The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
38.9K