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Thiabendazole/bentonites hybrids as controlled release systems.
Graycyelle R S Cavalcanti1, Maria G Fonseca2, Edson C da Silva Filho3
1Núcleo de Pesquisa e Extensão - Laboratório de Combustíveis e Materiais (NPE - LACOM), Universidade Federal da Paraíba, Cidade Universitária, s/n - Castelo Branco III, 58051-085, João Pessoa, PB, Brazil; Sorbonne Université, Laboratoire d'Archéologie Moléculaire et Structurale, CNRS UMR 8220, Tour 23, 3ème étage, couloir 23-33, BP 225, 4 place Jussieu, 75005, Paris, France.
Colloids and Surfaces. B, Biointerfaces
|January 10, 2019
Summary
Clay minerals like bentonites effectively sorbed thiabendazole (TBZ) for pharmaceutical use. These clay-drug hybrids show potential as controlled release systems, demonstrating tunable drug delivery capabilities.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Clay minerals are widely utilized in pharmaceuticals as excipients and active agents.
- Development of novel drug delivery vehicles is crucial for enhancing therapeutic efficacy.
- Bentonites, a type of clay mineral, offer unique properties for drug encapsulation and controlled release.
Purpose of the Study:
- To evaluate the sorption of thiabendazole (TBZ) onto sodium (BentNa), calcium (BentCa), and magnesium (BentMg) exchanged bentonites.
- To investigate the potential of these bentonite-thiabendazole hybrids as controlled drug release systems.
- To characterize the physicochemical properties of the bentonite materials and their drug interactions.
Main Methods:
- Characterization of pristine and exchanged bentonites using X-ray diffraction, infrared spectroscopy, thermogravimetry, and transmission electron microscopy (TEM).
- Sorption experiments to determine the influence of pH, contact time, and initial drug concentration on thiabendazole uptake.
- Drug release studies in simulated body fluids and kinetic analysis using the Korsmeyer-Peppas model.
Main Results:
- Maximum adsorption of thiabendazole was achieved within 45-105 minutes, with maximum adsorbed quantities of 164.4 mg/g (BentNa), 152.3 mg/g (BentCa), and 133.3 mg/g (BentMg).
- The sorption capacity was influenced by parameters including pH, contact time, and initial drug concentration.
- Drug emission profiles from bentonite/drug hybrids were consistent in simulated body fluids and followed Korsmeyer-Peppas kinetics.
Conclusions:
- Exchanged bentonites demonstrate significant potential for thiabendazole sorption and can be utilized as effective controlled drug release systems.
- The characterized bentonite-drug hybrids offer tunable drug delivery profiles suitable for pharmaceutical applications.
- Further research into these clay-based drug delivery systems could lead to advanced therapeutic formulations.
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