Related Experiment Video
Updated: Jan 31, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Thiabendazole/bentonites hybrids as controlled release systems
Graycyelle R S Cavalcanti1, Maria G Fonseca2, Edson C da Silva Filho3
1Núcleo de Pesquisa e Extensão - Laboratório de Combustíveis e Materiais (NPE - LACOM), Universidade Federal da Paraíba, Cidade Universitária, s/n - Castelo Branco III, 58051-085, João Pessoa, PB, Brazil; Sorbonne Université, Laboratoire d'Archéologie Moléculaire et Structurale, CNRS UMR 8220, Tour 23, 3ème étage, couloir 23-33, BP 225, 4 place Jussieu, 75005, Paris, France.
Abstract:
Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L-1 of thiabendazole to BentNa and after 105 min with 1300 mg L-1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g-1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.
Related Concept Videos
Control Systems
At the heart...
Control Systems: Applications
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
Feedback control systems
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
Open and closed-loop control systems
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
Transfer Function in Control Systems
To derive the transfer function, consider a general nth-order linear time-invariant...
Hybrid Zones

