Related Experiment Video

Updated: Jan 31, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.2K

A potential serious complication in infants with congenital obstructive uropathy: Secondary pseudohypoaldosteronism

Sabriye Korkut1, Leyla Akin2, Nihal Hatipoglu2

  • 1Department of Neonatology, Erciyes University Medical Faculty, Turkey.

JPMA. the Journal of the Pakistan Medical Association
|January 10, 2019
PubMed

Insights

Secondary pseudohypoaldosteronism (PHA) in infants is often linked to urinary issues. Prompt treatment of urinary tract infections can resolve PHA, especially in cases of obstructive uropathy.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Endocrinology

Background:

  • Secondary pseudohypoaldosteronism (PHA) presents with hyponatremia, hyperkalemia, and elevated serum aldosterone.
  • This condition can be associated with congenital anomalies and urinary tract issues in infants.

Purpose of the Study:

  • To investigate the causes and outcomes of secondary PHA in infants.
  • To evaluate the efficacy of treating underlying conditions, specifically urinary tract infections (UTIs), on PHA recovery.

Main Methods:

  • Retrospective analysis of eight infant patients diagnosed with secondary PHA.
  • Review of patient history, including underlying causes (obstructive uropathy, ileostomy), co-existing conditions (UTI), and treatment interventions.

Main Results:

  • Seven out of eight patients had PHA secondary to obstructive uropathy (OUP); one had PHA secondary to ileostomy.
  • Six OUP patients had concurrent UTIs; PHA resolved in most with UTI treatment alone, prior to surgical correction.
  • Recurrent salt wasting occurred in three patients with posterior urethral valves (PUV) during UTI episodes before three months of age.

Conclusions:

  • Obstructive uropathy is a significant cause of secondary PHA in young infants.
  • Treatment of urinary tract infections can effectively resolve secondary PHA in many cases, potentially avoiding early surgical intervention.
  • Close monitoring for recurrent salt wasting is crucial in infants with PUV and a history of UTIs.

Keywords:
Obstructive uropathy,salt wasting, Ileostomy, Secondary pseudohypoaldosteronism, Urinary tract infection, Prune Belly syndrome.

More Related Videos

P50 Sensory Gating in Infants12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Author Spotlight: Capturing Infant-Caregiver Interactions Through Synchronized Multimodal Data Collection08:08

Author Spotlight: Capturing Infant-Caregiver Interactions Through Synchronized Multimodal Data Collection

Published on: May 31, 2024

1.6K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.7K
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
137.8K
Secondary Healthcare System01:11

Secondary Healthcare System

Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.1K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
808
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.5K
Secondary Distribution01:25

Secondary Distribution

Secondary distribution systems provide electrical energy at the utilization voltage levels from distribution transformers to customer meters. Typical secondary voltages in the United States include 120/240 V for residential use, 208Y/120 V for residential and commercial use, and 480Y/277 V for industrial and high-rise commercial use.
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...
575