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Updated: Jan 31, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Progress in diagnosing and managing cardiac amyloidosis
Mazen Hanna1, Chetan Huded2, E Rene Rodriguez3,4
1Co-Director, Amyloidosis Center, Section of Heart Failure and Cardiac Transplant Medicine, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA. hammam@ccf.org.
Diagnosing and treating cardiac amyloidosis has significantly improved. Early detection is now possible with noninvasive tests, and new therapies are safe and effective.
Area of Science:
- Cardiology
- Medical Diagnostics
- Pharmacology
Background:
- Cardiac amyloidosis is a progressive condition.
- Recent years have brought significant advancements in managing this disease.
Purpose of the Study:
- To review the progress in diagnosing and treating cardiac amyloidosis.
- To highlight the impact of new diagnostic and therapeutic strategies.
Main Methods:
- Review of recent literature on cardiac amyloidosis.
- Analysis of noninvasive diagnostic techniques.
- Evaluation of current treatment options.
Main Results:
- Noninvasive laboratory testing and imaging enable earlier diagnosis.
- New therapeutic agents demonstrate high efficacy and tolerability.
- Improved patient outcomes are achievable with timely intervention.
Conclusions:
- The diagnosis and treatment landscape for cardiac amyloidosis has been revolutionized.
- Early detection and effective, well-tolerated treatments offer improved prognosis.
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