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Myricetin inhibits panel of kinases implicated in tumorigenesis

Stefani Stoll1, Shanna Bitencourt1, Stefan Laufer2

  • 1Cell Culture Laboratory, Postgraduate Program in Biotechnology, University of Taquari Valley (Univates), Lajeado, Brazil.

Basic & Clinical Pharmacology & Toxicology
|January 10, 2019
PubMed

Insights

Myricetin, a flavonoid, effectively inhibits tumor necrosis factor-alpha (TNF-α) release and multiple cancer-related kinases. This suggests myricetin

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Myricetin is a flavonoid with known antioxidant and anti-inflammatory properties.
  • Protein kinases play crucial roles in inflammation and carcinogenesis pathways.
  • Inhibiting these kinases is a key strategy for managing chronic diseases and cancer.

Purpose of the Study:

  • To evaluate the potential of 14 flavonoids in inhibiting TNF-α release.
  • To assess the inhibitory effects of myricetin on specific kinases involved in tumorigenesis.

Main Methods:

  • In vitro screening of 14 flavonoids for TNF-α inhibition in human whole blood.
  • Assay of myricetin's inhibitory activity against a panel of tumorigenesis-related kinases.

Main Results:

  • Myricetin demonstrated the most potent inhibition of TNF-α release among all tested flavonoids.
  • Myricetin exhibited multi-kinase inhibitory activity, reducing 7 kinases by over 70% and 9 kinases by over 90%.

Conclusions:

  • Myricetin possesses significant inhibitory effects on TNF-α and multiple tumorigenic kinases.
  • These findings highlight myricetin's therapeutic potential for developing novel anti-cancer agents.
Keywords:
TNF-αcancerflavonoidkinasemyricetin

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