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Essential oils in nanostructured systems: Challenges in preparation and analytical methods
Sheila Porto de Matos1, Leticia G Lucca1, Letícia S Koester1
1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Santa Cecília, 90610-000 Porto Alegre, RS, Brazil.
Talanta
|January 11, 2019
Summary
Encapsulating volatile essential oils in nanostructures for pharmaceutical use is growing. However, many preparation methods risk damaging the oils, and quantification of encapsulation efficiency is often overlooked or inaccurate.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Analytical Chemistry
Background:
- Essential oils, natural plant extracts with medicinal properties, are gaining pharmaceutical interest.
- Encapsulation of essential oils into nanometric systems is a rising trend for therapeutic applications.
- Research is expanding on utilizing nanostructured systems for essential oil delivery.
Purpose of the Study:
- To review and analyze research on essential oil encapsulation in organic nanostructured systems.
- To identify common preparation techniques and analytical quantification methods used in the field.
- To assess the suitability of analytical methods for determining encapsulation efficiency.
Main Methods:
- Data survey and analysis of published research papers on essential oil nanocarriers.
- Identification of organic nanostructured systems and their preparation methodologies.
- Evaluation of analytical quantification techniques for essential oil content and encapsulation efficiency.
Main Results:
- Many essential oil encapsulation techniques involve heating or solvent evaporation, potentially degrading the oils.
- Quantification of essential oil content in nanocarriers is frequently ignored or performed indirectly.
- Over half of the studies reviewed either ignored quantification or used indirect methods, assuming no loss.
- The suitability of analytical methods for assessing encapsulation efficiency requires careful consideration.
Conclusions:
- The integrity of essential oils during nanocarrier formulation is a significant concern.
- Accurate quantification of essential oil encapsulation efficiency is often lacking in current research.
- There is a need for validated analytical methods to reliably assess essential oil loading in nanostructures.
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