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Updated: Jan 31, 2026

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS
Published on: January 22, 2017
Size exclusion chromatography - Inductively coupled plasma - Mass spectrometry for determining metal-low molecular
Mónica Latorre1, Paloma Herbello-Hermelo2, Carlos Peña-Farfal3
1Department of Instrumental Analysis. Faculty of Pharmacy. University of Concepción, PO Box 237, 4070043 Concepción. Chile.
Abstract:
Size exclusion chromatography (SEC) hyphenated to inductively coupled plasma - mass spectrometry (ICP-MS), as a specific detector for metals, has been used for monitoring and determining metal-low molecular weight organic compound (LMWC) complexes in natural wines. SEC with UV detection (wavelength of 205 nm) was used for monitoring organic compounds eluted from the chromatographic column. SEC-UV has revealed the presence of low molecular weight compounds (commonly three fractions of molecular weights ranging from 230 to 1579 Da).' Further experiments using ICP-MS as a detector showed that elements such as B, Cu, Li, Mn, Ni, Ti, and Zn are bound to compounds of molecular weights within the 338-1579 Da range. Total metal concentrations, as well as metal concentrations in SEC fractions were also assessed in several monovarietal red (five varieties) and monovarietal white (three varieties) wines.
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