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Use of Human Perivascular Stem Cells for Bone Regeneration
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The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes
Smaranda Dana Buduru1,2, Diana Gulei3, Alina-Andreea Zimta4
1Prosthetics and Dental Materials, Faculty of Dental Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania. dana.buduru@umfcluj.ro.
Cells
|January 11, 2019
Summary
Choosing the right stem cells for bone regeneration is crucial. This review compares embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells, considering ethical and practical factors for dental applications.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Dental Research
Background:
- Tissue engineering advances rely on stem cell technology for regeneration.
- Selecting the optimal stem cell type remains a challenge for researchers.
- Bone regeneration in dentistry requires careful consideration of stem cell strategies.
Purpose of the Study:
- To review the pros and cons of three main stem cell categories for dental bone regeneration.
- To guide researchers in choosing the most suitable stem cell strategy.
- To highlight factors influencing stem cell selection beyond technical advantages.
Main Methods:
- Comparative review of stem cell types.
- Analysis of advantages and disadvantages for bone regeneration.
- Consideration of clinical applicability and ethical standards.
Main Results:
- Embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells offer distinct benefits and drawbacks.
- Selection criteria must align with the severity of dental conditions.
- Availability, collection invasiveness, and ethics are critical decision parameters.
Conclusions:
- The choice of stem cells for dental bone regeneration depends on a balance of efficacy, safety, and ethical considerations.
- Mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells each present unique profiles for regenerative dentistry.
- Practical and ethical factors significantly impact the clinical translation of stem cell therapies for bone defects.
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