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Published on: August 9, 2013
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Sepsis associated acute kidney injury
Jason T Poston1, Jay L Koyner2
1Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
BMJ (Clinical Research Ed.)
|January 11, 2019
Summary
Sepsis-associated acute kidney injury (SA-AKI) is a major complication of sepsis, impacting kidney function and patient outcomes. This review covers SA-AKI
Area of Science:
- Nephrology
- Critical Care Medicine
- Infectious Diseases
Background:
- Sepsis-associated acute kidney injury (SA-AKI) is a significant complication of sepsis, leading to increased morbidity and mortality.
- Kidney dysfunction is a common consequence of the host's response to infection.
- Despite advances, SA-AKI remains a substantial clinical burden requiring further investigation.
Purpose of the Study:
- To review current evidence on sepsis-associated acute kidney injury (SA-AKI).
- To focus on risk factors, diagnosis, treatment, and long-term consequences of SA-AKI.
- To synthesize information on SA-AKI within the broader context of sepsis and acute kidney injury.
Main Methods:
- Comprehensive literature review.
- Inclusion of studies on SA-AKI, sepsis, and acute kidney injury.
- Focus on clinical risk factors, pathobiology, treatment response, and renal recovery.
Main Results:
- Knowledge of clinical risk factors, pathobiology, and treatment has advanced.
- SA-AKI continues to be a significant concern with considerable clinical impact.
- Further research is essential to mitigate acute and chronic SA-AKI consequences.
Conclusions:
- SA-AKI is a critical manifestation of sepsis affecting kidney function.
- Understanding risk factors and improving early diagnosis are key.
- Effective treatment and management strategies are needed to reduce long-term renal consequences.
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