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Published on: June 11, 2019
Management of Inflammatory Cardiac Masses
Ankur A Karnik1, Eric H Awtry1
1Section of Cardiology, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA.
Insights
Systemic inflammatory disorders can cause cardiac masses. Conservative management may be effective, but requires careful consideration of risks like embolization.
Area of Science:
- Rheumatology
- Cardiology
- Pathology
Background:
- Systemic rheumatologic and inflammatory disorders frequently impact multiple organ systems, including the cardiovascular system.
- Cardiac structures such as valves, conduction system, myocardium, endocardium, pericardium, and coronary arteries are susceptible to these inflammatory processes.
- Intracardiac masses can arise directly from the disease or as a complication of treatment, like methotrexate-associated nodulosis.
Observation:
- Three cases of inflammatory cardiac masses associated with rheumatoid arthritis and Wegener's granulomatosis are presented.
- These masses require differentiation from thrombus, infection, and neoplastic tumors.
- Conservative management was successfully employed in the presented cases.
Findings:
- Inflammatory cardiac masses can occur in patients with systemic rheumatologic conditions.
- Conservative treatment approaches can be successful for these masses.
- Differentiating inflammatory masses from other cardiac lesions is crucial for appropriate management.
Implications:
- A proposed management algorithm for inflammatory cardiac masses is presented.
- Individualized treatment decisions are necessary, balancing conservative management against surgical risks.
- Potential complications such as systemic embolization, stroke, and obstruction must be carefully weighed.
Abstract:
Systemic rheumatologic and inflammatory disorders can affect almost any organ system, including the heart. The cardiac valves, conduction system, myocardium, endocardium, pericardium, and coronary arteries may be affected. Intracardiac masses may develop as part of the disease process or a consequence of their therapy, such as methotrexate-associated nodulosis. Optimal therapy in these cases is not known, since many patients are asymptomatic and the potential benefit of surgical excision must be weighed against its associated morbidity and mortality. Importantly, these inflammatory masses must be differentiated from thrombus, infection, and primary and metastatic tumors. We present three cases of inflammatory cardiac masses associated with rheumatoid arthritis and Wegener's granulomatosis, which were successfully treated conservatively, and propose a management algorithm. The benefits of such an approach must be individualized and weighed against the risks of systemic embolization, stroke and obstruction.
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