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Updated: Jan 31, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
Base-induced reversible H2 addition to a single Sn(ii) centre
Roland C Turnell-Ritson1, Joshua S Sapsford1, Robert T Cooper1
1Department of Chemistry , Imperial College London , London , SW7 2AZ , UK .
Abstract:
A range of amines catalyse the oxidative addition (OA) of H2 to [(Me3Si)2CH]2Sn (1), forming [(Me3Si)2CH]2SnH2 (2). Experimental and computational studies point to 'frustrated Lewis pair' mechanisms in which 1 acts as a Lewis acid and involve unusual late transition states; this is supported by the observation of a kinetic isotope effect for Et3N. When DBU is used the energetics of H2 activation are altered, allowing an equilibrium between 1, 2 and adduct [1·DBU] to be established, thus demonstrating reversible oxidative addition/reductive elimination (RE) of H2 at a single main group centre.
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