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[Mucociliary transport and bronchial inflammation].
1Ruhrlandklinik, Zentrum für Pneumologie und Thoraxchirurgie, Essen-Heidhausen.
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|June 15, 1988
Summary
Mucociliary clearance removes airway irritants, but disorders like primary ciliary dyskinesia and acquired inflammation can impair this vital function. Early treatment and ciliary stimulation are key therapeutic strategies.
Area of Science:
- Respiratory physiology
- Cell biology
Context:
- Mucociliary clearance is crucial for airway defense.
- Disruptions can be congenital (e.g., primary ciliary dyskinesia) or acquired.
Purpose:
- To review the mechanisms of mucociliary clearance dysfunction.
- To discuss the impact of inflammation on mucociliary transport.
Summary:
- Acquired disturbances, particularly from inflammation (infectious and noninfectious), frequently impair mucociliary clearance.
- Infections can cause long-lasting ciliostatic/ciliotoxic effects, while noninfectious inflammation initially excites then depresses transport.
- Therapies include anti-infectives and beta-adrenergic drugs to stimulate ciliary beating.
Impact:
- Understanding these mechanisms is vital for managing airway diseases.
- Highlights the reversible and irreversible nature of mucociliary transport disorders.
- Informs therapeutic strategies for improving airway clearance.