Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Conversion02:08

Gene Conversion

10.6K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.6K
Gene Conversion02:08

Gene Conversion

3.0K
3.0K
Genomics02:02

Genomics

40.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.6K
Conversion of Units01:36

Conversion of Units

36.2K
Sometimes, there is a need to convert from one unit to another one. For instance, reading a cookbook in which quantities are expressed in units of liters or ounces may require conversion of quantities to cups. Or, when looking up directions on how to get to a location, we may be interested to know how many miles we are going to walk. In this case, we would have to convert units of feet or meters to miles.
The first step in the unit conversion is to list the given units and the units required...
36.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Putting control into parents' hands: Parent experiences with a genomic results e-booklet.

Journal of genetic counseling·2025
Same author

Leveraging prior mean models for faster Bayesian optimization of particle accelerators.

Scientific reports·2025
Same author

Promoting Slhánay̓ Sḵwálwen (Indigenous Women's Heart Health): Findings From Sharing Circles With Squamish Nation.

Journal of nutrition education and behavior·2024
Same author

Pathways: A guide for developing culturally safe and appropriate patient-reported outcome (PROMs) and experience measures (PREMs) with Indigenous peoples.

Journal of evaluation in clinical practice·2023
Same author

Addressing the need for Indigenous-specific PROMs and PREMS: A focus on methodology.

Journal of evaluation in clinical practice·2023
Same author

Active Q-Switched X-Ray Regenerative Amplifier Free-Electron Laser.

Physical review letters·2023

Related Experiment Video

Updated: Jan 30, 2026

Assessment and Communication for People with Disorders of Consciousness
07:37

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

9.6K

Indigenous Peoples and genomics: Starting a conversation.

Jenny Morgan1, Rachel R Coe2, Rochelle Lesueur1

  • 1Indigenous Health Program, BC Women's and Children's Hospitals, Vancouver, BC, Canada.

Journal of Genetic Counseling
|January 11, 2019
PubMed
Summary

Indigenous Canadians face challenges with genomic sequencing due to underrepresentation in databases. This study highlights concerns about data governance, trust, and systemic racism, advocating for Indigenous-controlled data initiatives.

Keywords:
First NationsIndigenous Peoplesgenetic testing disparitiesgenomic sequencinghealthcare inequityreconciliationreference databases

More Related Videos

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

4.2K

Related Experiment Videos

Last Updated: Jan 30, 2026

Assessment and Communication for People with Disorders of Consciousness
07:37

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

9.6K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

4.2K

Area of Science:

  • Genomics
  • Bioethics
  • Indigenous Health

Background:

  • Indigenous Canadians are disproportionately affected by uninterpretable genome-wide sequencing results.
  • This inequity stems from the underrepresentation of Indigenous genomes in global reference databases.
  • Lack of representation perpetuates health disparities and limits the utility of genomic medicine for Indigenous populations.

Purpose of the Study:

  • To initiate a dialogue with Indigenous Canadians regarding genomic data representation and its implications.
  • To raise awareness about genomic non-representation and its impact on Indigenous health outcomes.
  • To co-create educational resources that incorporate Indigenous perspectives on genomic data.

Main Methods:

  • Conducted focus groups with 30 First Nations, Métis, and Inuit individuals in Greater Vancouver.
  • Participants engaged in discussions after viewing an introductory video on genomic testing.
  • Transcripts were analyzed thematically, with participant quotes integrated into a co-created awareness video.

Main Results:

  • Key themes emerged: systemic racism, trust, data governance, privacy, and fear of discrimination.
  • Participants expressed a need for Indigenous control over genomic data, with divided opinions on separate vs. international databases.
  • Emphasis was placed on obtaining prior approval from Indigenous leaders for data collection and implementation.

Conclusions:

  • Addressing genomic inequity requires centering Indigenous voices and concerns.
  • Building trust and ensuring data sovereignty are crucial for equitable genomic research and healthcare.
  • Co-created resources can empower Indigenous communities and foster informed discussions on genomic data usage.