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Cerebrospinal Fluid Pleocytosis following Meningococcal B vaccination in an Infant

Godwin Oligbu

    Epidemiologie, Mikrobiologie, Imunologie : Casopis Spolecnosti Pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti J.E. Purkyne
    |January 12, 2019
    PubMed

    Insights

    Cerebrospinal fluid pleocytosis was observed in an infant following meningococcal B vaccination. Clinicians should exercise caution when interpreting cerebrospinal fluid findings in children post-vaccination.

    Area of Science:

    • Pediatrics
    • Immunology
    • Neurology

    Background:

    • Meningococcal serogroup B (MenB) vaccines are crucial for preventing invasive meningococcal disease.
    • Post-vaccination inflammatory responses can sometimes manifest with neurological symptoms.

    Purpose of the Study:

    • To report a case of cerebrospinal fluid (CSF) pleocytosis in an infant after MenB vaccination.
    • To advise clinicians on the interpretation of CSF findings in the context of recent MenB vaccination.

    Main Methods:

    • Case report detailing clinical presentation, diagnostic workup, and outcomes.
    • Review of relevant literature on post-vaccination inflammatory responses.

    Main Results:

    • An infant developed CSF pleocytosis after receiving the first dose of a multicomponent MenB vaccine.
    • No other cause for pleocytosis was identified, suggesting a possible vaccine-related inflammatory response.

    Conclusions:

    • Cerebrospinal fluid pleocytosis can occur in infants post-MenB vaccination.
    • Further research and clear guidelines are needed for interpreting CSF findings in this clinical scenario.

    Keywords:
    meningococcal B vaccine - cerebrospinal fluid pleocytosis - inflammatory response - infant

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