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Related Concept Videos

Roles of Electrolytes: Calcium and Phosphate01:27

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Updated: Jan 30, 2026

Synthesis and Characterization of Fe-doped Aluminosilicate Nanotubes with Enhanced Electron Conductive Properties
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Epithelial cell functionality on electroconductive Fe/Sr co-doped biphasic calcium phosphate.

Subhadip Basu1, Aritri Ghosh2, Ananya Barui2

  • 11 Laboratory for Biomaterials, Materials Research Center, Indian Institute of Science, Bangalore, India.

Journal of Biomaterials Applications
|January 12, 2019
PubMed
Summary

Iron and strontium co-doped biphasic calcium phosphate (BCP) bioceramics show increased conductivity, enhancing epithelial cell viability and function for dental implant coatings. This research validates their potential for improved dental restorations and reduced infection risk.

Keywords:
Biphasic calcium phosphateE-cadherincellular polaritycytocompatibilityepithelial cellsstrontium and iron doping

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Area of Science:

  • Biomaterials Science
  • Dental Materials Science
  • Cell Biology

Background:

  • Dental implants require materials that interact favorably with bone, gingival, and connective tissues.
  • The interaction of implant coatings with epithelial cells is crucial for successful integration but requires further scientific validation.
  • Co-doped bioceramics, specifically iron (Fe) and strontium (Sr) in biphasic calcium phosphate (BCP), offer unexplored potential for dental applications.

Purpose of the Study:

  • To quantitatively evaluate the electrical properties of Fe/Sr co-doped BCP samples.
  • To assess the cytocompatibility of these co-doped BCPs with epithelial (vero) cells.
  • To investigate the impact of co-doping on epithelial cell adhesion, viability, functionality, and marker expression.

Main Methods:

  • Sol-gel synthesis was used to prepare Sr/Fe co-doped BCPs with varying dopant concentrations.
  • Electrical conductivity of the prepared samples was measured.
  • Cellular studies involved assessing cell viability, functionality, and adhesion on the BCP samples.
  • Real-time PCR and immunofluorescence were employed to analyze the expression of epithelial markers (E-cadherin, β-catenin) and polarity proteins (PARD3).

Main Results:

  • Co-doping with Sr/Fe significantly increased the electrical conductivity of BCP, with conductivity rising with higher dopant concentrations.
  • Cellular studies demonstrated a significant increase in epithelial cell viability and functionality correlated with increased sample conductivity (p=0.01).
  • Epithelial cell adhesion was enhanced, and expression of E-cadherin and PARD3 significantly increased (p=0.01) in co-doped samples, indicating improved epithelial sealing and cellular organization.
  • β-catenin expression remained unchanged, suggesting no tumorigenic potential.

Conclusions:

  • Fe/Sr co-doped BCPs exhibit enhanced electrical conductivity and promote epithelial cell adhesion, viability, and functionality.
  • These findings establish Sr/Fe co-doped BCPs as promising candidates for dental implant coatings, facilitating faster epithelial sealing and potentially reducing infection.
  • The modulation of epithelial marker expression and cellular polarity proteins highlights the material's biocompatibility and suitability for dental restorative applications.