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Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?

Luana Rossato1, Arnaldo Lopes Colombo1

  • 1Special Mycology Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil.

Frontiers in Microbiology
|January 12, 2019
PubMed

Insights

Candida auris is a multidrug-resistant fungus that spreads easily in healthcare settings. This study explores its virulence factors, explaining its unique transmission capabilities and pathogenicity.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Emergence of multidrug-resistant *Candida auris* as a global healthcare-associated pathogen.
  • Comparative analysis indicating fewer canonical virulence factors in *C. auris* versus *Candida albicans*.
  • Unique transmission patterns of *C. auris* within and between healthcare facilities.

Purpose of the Study:

  • To investigate the virulence and pathogenicity aspects of *Candida auris*.
  • To understand the factors contributing to the unique transmissibility of *C. auris*.
  • To elucidate the mechanisms underlying *C. auris* colonization and environmental persistence.

Main Methods:

  • Literature review and synthesis of existing research on *Candida auris* virulence.
  • Comparative analysis of virulence factor expression between *C. auris* and other *Candida* species.
  • Discussion of epidemiological data related to *C. auris* transmission.

Main Results:

  • *Candida auris* exhibits unique transmission dynamics despite expressing fewer virulence factors than *Candida albicans*.
  • Factors facilitating skin colonization and environmental persistence appear crucial for *C. auris* spread.
  • The yeast's pathogenicity is linked to its ability to thrive in healthcare environments.

Conclusions:

  • *Candida auris*'s global emergence is driven by factors beyond traditional virulence, including enhanced colonization and persistence.
  • Understanding these specific pathogenicity mechanisms is key to controlling the spread of this multidrug-resistant fungus.
  • Further research into *C. auris* virulence is essential for developing effective treatment and prevention strategies.
Keywords:
Candida aurisbiofilmsgenomicspathogenicityphenotypic traitsthermic and osmotic stressvirulence

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