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Updated: Jan 30, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Electroconvulsive therapy: 80 years old and still going strong
Gábor Gazdag1, Gabor S Ungvari2
1First Department of Psychiatry and Psychiatric Rehabilitation, Jahn Ferenc South Pest Hospital, Budapest 1204, Hungary.
Electroconvulsive therapy (ECT), a historically controversial psychiatric treatment, has evolved significantly over 80 years. Despite its effectiveness in treating severe conditions like catatonia, negative perceptions hinder its modern use.
Area of Science:
- Psychiatry
- Neuroscience
- Medical History
Background:
- Electroconvulsive therapy (ECT) is an 80-year-old psychiatric treatment with a controversial history.
- Its discovery by Laszló Meduna and the subsequent development by Ugo Cerletti and Lucio Bini are detailed.
- Meduna's initial epilepsy-schizophrenia antagonism theory has been superseded by modern hypotheses on ECT's mechanism of action.
Discussion:
- ECT remains a vital treatment for specific psychiatric conditions, including catatonia and severe affective/psychotic states.
- Its efficacy in life-threatening situations like postpartum psychosis is highlighted.
- Adverse effects and comparisons with newer brain stimulation techniques are reviewed.
Key Insights:
- Negative public and professional perceptions of ECT persist due to historical misuse and media portrayal.
- These negative attitudes have led to decreased ECT utilization and restricted patient access.
- Reduced access to ECT may infringe upon patients' rights to effective psychiatric care.
Outlook:
- Addressing the stigma surrounding ECT is crucial for its appropriate clinical application.
- Further research into ECT's mechanisms and comparative effectiveness is warranted.
- Ensuring equitable patient access to ECT aligns with modern psychiatric care standards.
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Electroconvulsive Therapy
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A titration is carried out for 25.00 mL of 0.100 M HCl (strong acid) with 0.100 M of a strong base NaOH. The pH at different volumes of added base solution can be calculated as follows:
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Strong Acid and Base Solutions
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