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Updated: Jan 30, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Salvation of the fallen angel: Reactivating mutant p53

Yang Li1, Zhuoyi Wang1, Yuchen Chen1

  • 1Tongji School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

British Journal of Pharmacology
|January 12, 2019
PubMed

Insights

Mutant forms of p53, crucial in many cancers, can be reactivated to restore anti-tumour functions. This review explores pharmacological strategies targeting these p53 mutants for cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The tumor suppressor protein p53, known as the guardian of the genome, is frequently mutated in human cancers.
  • Mutations in p53 lead to a loss of its tumor suppressor function and a gain of oncogenic properties, promoting cancer progression.
  • These mutant p53 proteins are implicated in over half of all human cancers, making them a significant therapeutic target.

Purpose of the Study:

  • To review the progress in reactivating mutant forms of p53.
  • To focus on the pharmacological mechanisms employed by compounds designed to restore the anti-tumor capacity of p53 mutants.

Main Methods:

  • This review summarizes existing research on p53 mutant reactivation strategies.
  • It focuses on various classes of therapeutic candidates, including small molecules, peptides, and nucleic acids.
  • The review emphasizes the pharmacological mechanisms through which these candidates function.

Main Results:

  • Numerous compounds have been identified or designed to target and reactivate p53 mutants.
  • These reactivators employ diverse mechanisms to restore the tumor suppressor function of mutant p53.
  • The development of effective p53 reactivators holds significant promise for cancer treatment.

Conclusions:

  • Targeting mutant p53 is a promising therapeutic strategy in oncology.
  • Pharmacological reactivation of mutant p53 aims to restore its tumor-suppressive functions.
  • Continued research into p53 reactivators could lead to novel cancer therapies.

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