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Activation and Conjugation of Soluble Polysaccharides using 1-Cyano-4-Dimethylaminopyridine Tetrafluoroborate CDAP
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Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

Yu-Hui Zhang1, Ying-Ming Zhang2, Jie Yu3

  • 1College of Science, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China and Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.

Chemical Communications (Cambridge, England)
|January 12, 2019
PubMed
Summary

Researchers developed a pH-responsive polysaccharide conjugate using hyaluronic acid and the anticancer drug bortezomib. This targeted conjugate shows controlled drug release in acidic conditions, reducing toxicity and enhancing cancer cell inhibition.

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