Related Experiment Video

Updated: Jan 30, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

29.9K

Maximum home systolic blood pressure is a marker of carotid atherosclerosis

Toshiki Kaihara1,2, Satoshi Hoshide2, Naoko Tomitani2

  • 1Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 12, 2019
PubMed

Insights

Maximum home systolic blood pressure (SBP) is a significant risk factor for hypertensive target organ damage. Measuring maximum SBP alongside mean SBP can improve risk assessment for cardiovascular complications.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Measurement

Background:

  • Blood pressure (BP) variability is a recognized clinical parameter.
  • Maximum home systolic blood pressure (SBP) has emerged as a key indicator of BP variability.
  • The role of maximum SBP as a risk factor for hypertensive target organ damage (TOD) requires further investigation.

Purpose of the Study:

  • To investigate the hypothesis that maximum home SBP is an independent risk factor for hypertensive target organ damage (TOD).
  • To compare the association of maximum SBP with TOD markers against mean SBP.

Main Methods:

  • A cross-sectional study involving 4,310 participants with at least one cardiovascular risk factor.
  • Home BP was monitored for 14 consecutive days.
  • Mean and maximum home SBP were analyzed as independent variables against TOD markers: left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (CIMT), and urine albumin creatinine ratio (UACR).

Main Results:

  • Both mean and maximum home SBP were significantly associated with all assessed TOD markers.
  • Maximum home SBP showed a statistically stronger association with carotid intima-media thickness (CIMT) compared to mean SBP (p<0.001).

Conclusions:

  • Maximum home SBP is a clinically significant parameter in assessing hypertensive target organ damage.
  • Routine measurement of maximum home SBP, in addition to mean home SBP, is recommended for comprehensive cardiovascular risk evaluation.

Keywords:
Blood pressure variabilitycarotid atherosclerosiscarotid intima-media thicknessmaximum systolic blood pressure

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

21.0K

Related Concept Videos

Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
10.1K
Blood Pressure01:30

Blood Pressure

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
4.4K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
3.0K
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
6.8K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.2K