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Monitoring hepatic function.

G P Zaloga1, D S Prough

  • 1Department of Anesthesiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.

Critical Care Clinics
|July 1, 1988
PubMed
Summary
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Monitoring liver health involves assessing hepatic function with exogenous and endogenous substances, alongside tests for hepatic necrosis and hepatobiliary system evaluation.

Area of Science:

  • Hepatology and clinical biochemistry

Background:

  • Hepatic function is crucial for overall health and can be assessed through various biomarkers.
  • Deterioration of liver function can indicate serious health issues, necessitating reliable monitoring methods.

Purpose of the Study:

  • To outline the comprehensive methods for monitoring hepatic function, detecting hepatic necrosis, and assessing the hepatobiliary system.
  • To provide an overview of commonly used exogenous and endogenous markers and diagnostic tools.

Main Methods:

  • Monitoring hepatic function using exogenous substances like sulfobromophthalein and indocyanine green.
  • Assessing hepatic function with endogenous substances including bile acids, albumin, and bilirubin.
  • Evaluating hepatic necrosis through liver enzymes such as aspartate aminotransferase and alanine aminotransferase.

Related Experiment Videos

  • Assessing the hepatobiliary system using alkaline phosphatase, gamma-glutamyl transpeptidase, and imaging techniques like ultrasound and iminodiacetic acid scans.

    • Main Results:

    • A wide array of exogenous and endogenous substances can effectively monitor liver function.
    • Specific enzymes like AST and ALT are key indicators of hepatic necrosis.
    • Various biochemical markers and imaging modalities provide a comprehensive assessment of the hepatobiliary system.

    Conclusions:

    • A multi-faceted approach utilizing exogenous/endogenous markers, necrosis tests, and hepatobiliary assessments is vital for thorough liver health monitoring.
    • These diverse methods collectively offer a robust framework for evaluating liver function and disease.