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Related Experiment Videos

Cefuroxime axetil.

M A Marx1, W K Fant

  • 1College of Pharmacy, University of Cincinnati, OH 45267.

Drug Intelligence & Clinical Pharmacy
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Cefuroxime axetil, an oral prodrug of cefuroxime, effectively treats various bacterial infections. Clinical studies show its comparable efficacy to other antibiotics for common infections.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Microbiology

Background:

  • Cefuroxime axetil is an orally administered prodrug of cefuroxime.
  • Upon absorption, it is rapidly converted to the active form, cefuroxime.
  • This formulation broadens the therapeutic options for cefuroxime administration.

Purpose of the Study:

  • To evaluate the in vitro antibacterial spectrum of cefuroxime axetil.
  • To assess its clinical efficacy in treating common bacterial infections.
  • To compare its effectiveness against established antibiotic therapies.

Main Methods:

  • In vitro susceptibility testing against various bacterial pathogens.
  • Clinical trials comparing cefuroxime axetil with ampicillin, amoxicillin, amoxicillin/clavulanic acid, penicillin V, and cefaclor.

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  • Evaluation of treatment outcomes for uncomplicated urinary tract infections, acute otitis media, upper respiratory infections, skin and soft tissue infections, and gonorrhea.

    • Main Results:

    • Cefuroxime axetil demonstrates in vitro activity against many gram-positive and some gram-negative organisms.
    • Its beta-lactamase stability is advantageous against resistant strains of Haemophilus influenzae, Branhamella catarrhalis, and Staphylococcus aureus.
    • Clinical studies indicate comparable efficacy to ampicillin, amoxicillin, amoxicillin/clavulanic acid, penicillin V, and cefaclor for specified infections.

    Conclusions:

    • Cefuroxime axetil is an effective oral antibiotic with a broad spectrum of activity.
    • Its beta-lactamase stability enhances its utility against resistant bacterial strains.
    • It represents a viable therapeutic option for various common bacterial infections, demonstrating comparable efficacy to other standard treatments.