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Memory function--effects of different antihypertensive drugs.

P J Richardson1, M A Wyke

  • 1Department of Cardiology, King's College Hospital, London.

Drugs
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Beta-blocker atenolol may cause mild memory impairment in patients with hypertension. Angiotensin-converting enzyme inhibitor enalapril showed no measurable effect on memory function during the study.

Area of Science:

  • Pharmacology
  • Neurology
  • Cardiology

Background:

  • Antihypertensive drug therapy is crucial for managing hypertension.
  • Potential cognitive side effects, specifically memory impairment, are a concern with some antihypertensive agents.
  • Previous studies have suggested a link between certain antihypertensives and memory function changes.

Purpose of the Study:

  • To investigate the effects of atenolol (a beta-blocker) and enalapril (an angiotensin-converting enzyme inhibitor) on memory function in patients with moderate essential hypertension.
  • To compare the memory function outcomes between atenolol and enalapril treatment groups against a placebo.

Main Methods:

  • A randomized, observer-blind study was conducted on patients with moderate essential hypertension.
  • Participants were treated with either atenolol or enalapril for 16 weeks.

Related Experiment Videos

  • Memory function was assessed using four everyday life-related tests during placebo and active treatment phases.

    • Main Results:

    • Both atenolol and enalapril effectively reduced diastolic blood pressure.
    • Enalapril significantly reduced systolic blood pressure (p < 0.05), while atenolol did not.
    • Memory performance scores decreased in the atenolol group compared to placebo in 9 out of 28 estimates.
    • No significant changes in memory function were observed in the enalapril group.

    Conclusions:

    • Atenolol may be associated with mild memory impairment in patients with moderate essential hypertension.
    • Enalapril demonstrated no measurable adverse effects on memory function in this patient group.
    • These findings suggest a differential impact of antihypertensive drug classes on cognitive function.