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Managing Risks with Biologics

Benjamin Click1, Miguel Regueiro2

  • 1Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

Current Gastroenterology Reports
|January 13, 2019
PubMed
Abstract

Insights

New biologic therapies for inflammatory bowel disease (IBD) like vedolizumab and ustekinumab present unique safety concerns. This review outlines risks and strategies for managing side effects in IBD patients.

Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Advanced targeted therapies are transforming inflammatory bowel disease (IBD) management.
  • Emerging biologic therapies introduce novel safety and side effect profiles.
  • Proactive risk assessment is crucial for effective IBD treatment.

Purpose of the Study:

  • To review the risks associated with advanced biologic therapies in IBD.
  • To discuss potential strategies for mitigating these risks.
  • To provide management recommendations for IBD treatment-related complications.

Main Methods:

  • Comprehensive review of clinical trial and real-world safety data for IBD therapies.
  • Analysis of safety data for vedolizumab, ustekinumab, and tofacitinib.
  • Evaluation of new vaccine data (varicella zoster virus, hepatitis B, influenza) in IBD patients.

Main Results:

  • Novel safety considerations arise with vedolizumab, ustekinumab, and tofacitinib.
  • Updated safety data for anti-tumor necrosis factor agents are presented.
  • New vaccine studies offer insights into infection prevention for IBD patients.

Conclusions:

  • Understanding risks of new IBD agents is vital for optimal clinical outcomes.
  • Implementing mitigating strategies can improve patient safety.
  • Effective management of side effects is key to maintaining treatment efficacy in IBD.
Keywords:
BiologicsCrohn’s diseaseInfectionSafetyUlcerative colitis

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