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Managing Risks with Biologics.

Benjamin Click1, Miguel Regueiro2

  • 1Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

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|January 13, 2019
PubMed
Summary
This summary is machine-generated.

New biologic therapies for inflammatory bowel disease (IBD) like vedolizumab and ustekinumab present unique safety concerns. This review outlines risks and strategies for managing side effects in IBD patients.

Keywords:
BiologicsCrohn’s diseaseInfectionSafetyUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Advanced targeted therapies are transforming inflammatory bowel disease (IBD) management.
  • Emerging biologic therapies introduce novel safety and side effect profiles.
  • Proactive risk assessment is crucial for effective IBD treatment.

Purpose of the Study:

  • To review the risks associated with advanced biologic therapies in IBD.
  • To discuss potential strategies for mitigating these risks.
  • To provide management recommendations for IBD treatment-related complications.

Main Methods:

  • Comprehensive review of clinical trial and real-world safety data for IBD therapies.
  • Analysis of safety data for vedolizumab, ustekinumab, and tofacitinib.
  • Evaluation of new vaccine data (varicella zoster virus, hepatitis B, influenza) in IBD patients.

Main Results:

  • Novel safety considerations arise with vedolizumab, ustekinumab, and tofacitinib.
  • Updated safety data for anti-tumor necrosis factor agents are presented.
  • New vaccine studies offer insights into infection prevention for IBD patients.

Conclusions:

  • Understanding risks of new IBD agents is vital for optimal clinical outcomes.
  • Implementing mitigating strategies can improve patient safety.
  • Effective management of side effects is key to maintaining treatment efficacy in IBD.