Related Experiment Video
Updated: Jan 30, 2026
08:29
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
10.5K
Modeling ncRNA-Mediated Circuits in Cell Fate Decision
Xiao-Jun Tian1, Manuela Vanegas Ferro2, Hanah Goetz2
1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA. xiaojun.tian@asu.edu.
Methods in Molecular Biology (Clifton, N.J.)
|January 13, 2019
Summary
Mathematical modeling clarifies how noncoding RNAs (ncRNAs) control cell fate. Reciprocal regulation between mRNA, miRNA, and ceRNA networks creates bistable switches essential for cell fate decisions.
Area of Science:
- Molecular Biology
- Systems Biology
- Computational Biology
Background:
- Noncoding RNAs (ncRNAs) are crucial for cell fate decisions.
- The precise molecular mechanisms of ncRNA-mediated bistable switches are not fully understood.
Purpose of the Study:
- To review and summarize the general framework of mathematical modeling for ncRNAs.
- To illustrate the application of these models in biological processes.
- To discuss the role of mathematical modeling in synthetic biology.
Main Methods:
- Systematic mathematical and quantitative experimental analyses.
- Review of existing literature on ncRNA modeling.
- Discussion of emergent properties in gene regulatory networks.
Main Results:
- Mathematical modeling provides a framework for understanding ncRNA-mediated cell fate.
- Reciprocal regulation between mRNA, microRNA (miRNA), and competing endogenous mRNA (ceRNA) networks contributes to bistability.
- Positive feedback loops involving ncRNAs and transcription factors are key to bistable switches.
Conclusions:
- Mathematical modeling is essential for elucidating complex ncRNA functions.
- Bistable switches, driven by intricate regulatory networks, direct cell fate decisions.
- The framework presented aids in understanding ncRNA roles in both natural and synthetic biological systems.
Related Concept Videos
01:20Fates of Pyruvate
10.8K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
10.8K
01:20Decision Making
965
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
965
01:19Personal Choice and Fate Attributions
171
Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
171
01:09Decision Making: P-value Method
6.9K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
6.9K
01:17Second-Order Circuits
3.5K
Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
3.5K
01:39Receptor-mediated Endocytosis
110.9K
Overview
110.9K