Related Experiment Video

Updated: Jan 30, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

375

Current concepts and techniques of vitrectomy for retinopathy of prematurity

Shunji Kusaka1

  • 1Department of Ophthalmology, Kindai University Faculty of Medicine, Osaka, Japan.

Taiwan Journal of Ophthalmology
|January 15, 2019
PubMed

Insights

Early intervention for retinopathy of prematurity (ROP) is crucial. For advanced ROP, timely vitrectomy surgery offers better outcomes at Stage 4A than Stage 5, preventing severe vision loss.

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Surgical Innovation

Background:

  • Retinopathy of prematurity (ROP) is a significant global cause of childhood blindness.
  • Timely screening and interventions like laser ablation and anti-VEGF therapy can manage ROP and prevent retinal detachment.
  • Some ROP cases are refractory to treatment, progressing to tractional retinal detachment (TRD) requiring surgery.

Purpose of the Study:

  • To evaluate the efficacy of surgical interventions for advanced stages of retinopathy of prematurity.
  • To compare outcomes of vitrectomy for Stage 4A versus Stage 5 ROP.
  • To provide guidance on optimal surgical timing for ROP-related tractional retinal detachment.

Main Methods:

  • Review of surgical interventions for retinopathy of prematurity.
  • Analysis of anatomical and functional outcomes following vitrectomy for Stage 4A and Stage 5 ROP.
  • Comparison of results between early (Stage 4A) and late (Stage 5) surgical intervention.

Main Results:

  • Vitrectomy for Stage 5 ROP (total retinal detachment) offers limited anatomical and functional benefits, though it may prevent complete blindness.
  • Vitrectomy, particularly lens-sparing vitrectomy, performed at Stage 4A ROP (partial TRD not involving the macula) yields significantly better anatomical and functional results.
  • Early surgical intervention in ROP is associated with improved patient outcomes.

Conclusions:

  • Surgical intervention for retinopathy of prematurity should be considered at the earliest feasible stage, ideally Stage 4A.
  • While vitrectomy for Stage 5 ROP has limitations, it remains a critical option for preventing total blindness.
  • Optimizing the timing of vitrectomy is key to maximizing visual preservation in ROP patients with tractional retinal detachment.

Keywords:
Antivascular endothelial growth factor therapylens-sparing vitrectomylensectomyretinal detachmentretinopathy of prematurityvitrectomy

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.2K
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

9.3K

Related Concept Videos

Self-Concept01:19

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
1.7K
Concepts and Prototypes01:24

Concepts and Prototypes

The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
538
Formula Mass and Mole Concepts of Compounds02:56

Formula Mass and Mole Concepts of Compounds

Formula Mass of Covalent Compounds
81.2K
Basic Concept01:28

Basic Concept

Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...
6.2K
Concept of Pressure at a Point01:15

Concept of Pressure at a Point

The concept of pressure at a point in a fluid establishes that pressure within a fluid is uniform in all directions at a specific location. This uniformity occurs because fluid molecules exert force evenly across any point due to their random motion and continuous collisions within the fluid. Pressure at a point is determined by the surrounding fluid molecules and is influenced by factors like depth and density, rather than by shape or orientation.
In a fluid at rest, pressure acts equally in...
746
Understanding Self-Concept01:20

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
277