Related Experiment Video
Updated: Jun 24, 2026
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Surgical Outcomes and Prognostic Factors in Morning Glory Syndrome-Associated Retinal Detachment
Sayaka Yamao1, Yasutaka Chiba2, Kazuki Kuniyoshi3
1Department of Ophthalmology, Aichi Medical University, Nagakute, Japan.
Purpose:
To evaluate surgical outcomes and identify key prognostic factors in retinal detachment (RD) associated with morning glory syndrome (MGS).
Design:
Retrospective consecutive case series.
Subjects:
Fifteen consecutive eyes of 15 patients with MGS-RD who underwent vitreoretinal surgery between 2000 and 2024 with a follow-up of >12 months.
Methods:
We retrospectively reviewed clinical records. We analyzed associations between 7 clinical factors and outcomes using logistic regression and exact statistical methods, including age, proliferative vitreoretinopathy (PVR) grade, funnel configuration, extent of RD, the presence of a visible break, complicated cataract, and application of endolaser around the excavated peripapillary area.
Main Outcome Measures:
Anatomic success was defined as retinal reattachment without silicone oil tamponade at final follow-up.
Results:
The final anatomic success rate was 46.7% (7/15). Proliferative vitreoretinopathy grade at the initial surgery showed the strongest association with anatomic outcomes, with a success rate of 11.1% (1/9) in eyes with grade C compared with 100% (6/6) in those with less advanced PVR. Younger age was also associated with poorer outcomes, with no successful cases in patients aged ≤3 years (0/5) and complete success in those aged ≥9 years (5/5). Eyes with an open-funnel configuration showed higher success rates than those with a closed-funnel configuration (7/10 vs. 0/5). A visible peripapillary break and absence of complicated cataract were also associated with better outcomes. Endolaser application showed no clear association with success.
Conclusions:
Advanced proliferative changes were strongly associated with poorer anatomic outcomes in MGS-RD. Younger age and advanced disease features, including closed-funnel configuration and complicated cataract, were also associated with poorer prognosis. Given the limited sample size and retrospective design, these findings should be interpreted as exploratory observations. Mild cases may initially be observed; however, we suggest that persistent or progressive detachment may warrant consideration of surgical intervention before severe proliferative progression develops.
Financial Disclosure(S):
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.