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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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What are Cells?01:07

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
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What is Cell Signaling?02:03

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Concentration Cells02:41

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
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Chemistry of the Cell02:58

Chemistry of the Cell

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The cell is chemically composed of water, organic molecules and inorganic ions.
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Updated: Jan 30, 2026

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
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Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

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Cell Senescence in Lupus.

Lin Gao1, Maria Slack1, Jennifer L Barnas

  • 1Allergy Immunology Rheumatology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Current Rheumatology Reports
|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state of irreversible cell cycle arrest, occurs in vivo and can be triggered by various factors. Research is exploring if accelerated senescence in lupus patients could inform new therapeutic strategies.

Keywords:
Cellular senescenceDNA damageMesenchymal stem cellsSystemic lupus erythematosusTelomeres

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Induction and Validation of Cellular Senescence in Primary Human Cells
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Area of Science:

  • Gerontology
  • Immunology
  • Cell Biology

Background:

  • Cellular senescence, initially observed in vitro, is now recognized as an in vivo phenomenon.
  • It can be induced by diverse stressors including radiation, chemotherapy, oncogene activation, metabolic issues, and chronic inflammation.

Purpose of the Study:

  • To investigate the potential occurrence of accelerated cellular senescence in systemic rheumatologic diseases, specifically lupus.
  • To explore whether cellular senescence contributes to the increased morbidity and mortality observed in lupus patients.

Main Methods:

  • This review synthesizes current knowledge on cellular senescence mechanisms and their potential relevance to systemic rheumatologic diseases.
  • It examines the link between cellular aging and disease progression in conditions like systemic lupus erythematosus.

Main Results:

  • Accelerated cellular aging is hypothesized as a contributing factor to the excess morbidity and mortality in lupus patients.
  • Understanding these mechanisms may reveal novel therapeutic targets.

Conclusions:

  • Targeting cellular senescence presents a promising avenue for developing new treatments to prevent long-term complications, such as organ failure, in systemic lupus erythematosus.
  • Further research is warranted to validate the role of senescence in lupus and evaluate senolytic therapies.