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Rapid automated liver quantitative susceptibility mapping.

Ramin Jafari1,2, Sujit Sheth3, Pascal Spincemaille2

  • 1Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Journal of Magnetic Resonance Imaging : JMRI
|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Automated quantitative susceptibility mapping (QSM) offers a faster and reproducible method for measuring liver iron concentration (LIC). This technique aids in guiding iron-chelating therapy for patients with transfusional iron overload.

Keywords:
in-phase echoesliver iron overloadquantitative susceptibility mappingwater/fat separation

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging
  • Quantitative Susceptibility Mapping

Background:

  • Accurate liver iron concentration (LIC) measurement is crucial for managing transfusional iron overload.
  • Quantitative susceptibility mapping (QSM) is investigated as a method to measure LIC.
  • Automated QSM aims to streamline LIC assessment for clinical use.

Purpose of the Study:

  • To develop a rapid, robust, and automated liver QSM method for clinical practice.
  • To assess the feasibility of automated QSM for LIC measurement.

Main Methods:

  • A prospective study involving 13 healthy subjects and 22 patients.
  • Data acquired using 1.5 T and 3 T/3D multiecho gradient-recalled echo (GRE) sequences.
  • An automated liver QSM pipeline using in-phase (IP) echo-based initialization was developed and compared to the SPURS method.

Main Results:

  • The IP echo-based initialization method for liver QSM was approximately 5.5 times faster than the SPURS method.
  • Liver QSM generated using the IP method demonstrated high reproducibility across four scanners (average R²=0.95, ICC=0.97).
  • The automated IP method provided robust water/fat separation and field estimation.

Conclusions:

  • In-phase (IP) echo-based initialization enables automated, rapid, and reproducible liver QSM.
  • This automated approach is suitable for clinical applications in assessing liver iron concentration.
  • The developed method facilitates efficient guidance of iron-chelating therapy.