Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

40.4K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
40.4K
Functions of Connective Tissues01:17

Functions of Connective Tissues

16.6K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
16.6K
Functional Groups02:45

Functional Groups

88.5K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.5K
Functional Groups02:45

Functional Groups

24.4K
24.4K
Tissues01:18

Tissues

85.2K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
85.2K
Structural Protein Function01:56

Structural Protein Function

29.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting.

bioRxiv : the preprint server for biology·2026
Same author

Advancing photocytotoxicity evaluation of nitric oxide derivative-ruthenium complex in 3D biofabricated breast cancer models.

Materials today. Bio·2026
Same author

Pancreatic tissue engineering: towards a vascularized bioengineered cure for diabetes.

Frontiers in transplantation·2026
Same author

Analytical Validation of NETest2.0<sup>®</sup>, a Novel Multigene Blood-Based Molecular Assay for Neuroendocrine Tumors.

Cancers·2026
Same author

Physiologically relevant 3D tumor models for therapeutic screening.

Biomaterials·2026
Same author

Droplet-based bioprinting.

Nature reviews. Methods primers·2026
Same journal

Corrigendum to "Senescent endothelial cells' response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis" [Acta Biomaterialia 166 (2023) 266-277].

Acta biomaterialia·2026
Same journal

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Acta biomaterialia·2026
Same journal

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function.

Acta biomaterialia·2026
Same journal

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.

Acta biomaterialia·2026
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.4K

Bioprinting functional tissues.

Ashley N Leberfinger1, Shantanab Dinda2, Yang Wu3

  • 1Department of Surgery, Penn State University College of Medicine, Hershey, PA 17033, USA.

Acta Biomaterialia
|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) bioprinting offers a promising solution to organ shortages by using patient cells to create replacement tissues. This paper explores challenges in bioprinting functional tissues for regenerative medicine.

Keywords:
Cell densityEngraftmentFunctional tissue bioprintingHeterogeneityInnervationMechanicsTransplantVascularization

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

17.4K
3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue
08:57

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

7.1K

Related Experiment Videos

Last Updated: Jan 30, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.4K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

17.4K
3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue
08:57

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

7.1K

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Tissue Engineering

Background:

  • Organ transplantation faces limitations including donor shortages and the need for lifelong immunosuppression.
  • Patient-specific cell-based therapies are emerging as a potential solution to overcome these challenges.
  • Three-dimensional (3D) bioprinting utilizes patient cells for fabricating functional tissues and organs.

Purpose of the Study:

  • To discuss the challenges in functionalizing bioprinted tissues for clinical translation.
  • To highlight eight critical dimensions for creating complex, volumetric tissues: biomimicry, cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function.
  • To inform future directions in the field of bioprinting for regenerative medicine.

Main Methods:

  • Review and discussion of existing literature on 3D bioprinting challenges.
  • Analysis of eight key factors influencing the functionality of bioprinted tissues.
  • Identification of research gaps and future research directions.

Main Results:

  • Several challenges impede the generation of clinically viable, large-scale bioprinted tissues.
  • Understanding and addressing factors like vascularization, innervation, and mechanics are crucial for functional tissue development.
  • Bioprinting methodologies require further refinement to achieve biologically relevant tissue complexity.

Conclusions:

  • 3D bioprinting holds significant potential to address organ shortages and revolutionize regenerative medicine.
  • Overcoming the discussed challenges is essential for the clinical translation of bioprinted tissues and organs.
  • Continued research focusing on tissue functionality and advanced bioprinting techniques will drive progress in the field.