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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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microRNAs in chronic kidney disease.
Hui Zhao1, Shi-Xing Ma2, You-Quan Shang2
1Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 15, 2019
Summary
MicroRNAs (miRNAs) play a key role in chronic kidney disease (CKD) progression. These molecules show potential as diagnostic biomarkers and therapeutic targets for managing CKD.
Area of Science:
- Nephrology
- Molecular Biology
- Biomarker Discovery
Background:
- Chronic kidney disease (CKD) presents a significant global health challenge, marked by high morbidity, mortality, and socioeconomic impact.
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various pathophysiological processes, including CKD.
- Altered miRNA expression is a documented feature of CKD, prompting research into their specific roles.
Purpose of the Study:
- To review current research on the involvement of miRNAs in the progression of chronic kidney disease.
- To highlight the potential of miRNAs as diagnostic biomarkers for CKD.
- To explore the therapeutic potential of targeting miRNAs in CKD treatment.
Main Methods:
- Literature review of recent studies investigating miRNA involvement in CKD.
- Analysis of research focusing on specific CKD states such as diabetic nephropathy, lupus nephritis, focal segmental glomerulosclerosis, and IgA nephropathy.
- Synthesis of findings regarding miRNA expression changes and their functional roles in CKD pathogenesis.
Main Results:
- Numerous studies demonstrate significant alterations in miRNA expression profiles in patients with CKD.
- Specific miRNAs are linked to the progression of various CKD subtypes, including diabetic nephropathy and IgA nephropathy.
- miRNAs are shown to influence key pathophysiological pathways relevant to kidney damage.
Conclusions:
- MicroRNAs are critically involved in the progression of chronic kidney disease.
- miRNAs represent promising candidates for developing novel diagnostic biomarkers for CKD.
- Targeting miRNAs offers a potential therapeutic strategy for the management of chronic kidney disease.
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