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Updated: Jan 30, 2026
04:12
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
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Subcutaneous Injection of Tranexamic Acid to Reduce Bleeding During Dermatologic Surgery: A Double-Blind,
Isaac Zilinsky1, Tami Brutman Barazani2, Denis Visentin3
1Mohs Unit, Sheba Medical Center, Tel Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Summary
Subcutaneous tranexamic acid (TXA) injection safely reduces bleeding in dermatologic surgery. This method is especially effective for patients on anticoagulants, improving hemostasis.
Area of Science:
- Dermatologic Surgery
- Pharmacology
- Hemostasis
Background:
- Tranexamic acid (TXA) is utilized systemically (oral, IV) and topically to mitigate surgical hemorrhage.
- Investigating novel delivery methods for TXA is crucial for enhancing surgical outcomes.
Purpose of the Study:
- To ascertain the safety and efficacy of subcutaneous tranexamic acid (TXA) injection for reducing blood loss during dermatologic procedures.
Main Methods:
- A double-blinded, placebo-controlled, randomized study involving 131 patients undergoing dermatologic surgery.
- Patients received either subcutaneous TXA or a saline placebo prior to surgery.
- Bleeding was quantified by bloodstain-to-wound size ratio and subjective hemostasis assessment.
Main Results:
- Subcutaneous TXA significantly reduced the bloodstain-to-wound size ratio compared to placebo (1.77 vs. 2.49, p < .001).
- TXA demonstrated enhanced efficacy in patients receiving anticoagulants.
- Subjective hemostasis scores were significantly improved with TXA, particularly in the anticoagulant subgroup.
Conclusions:
- Subcutaneous TXA injection is a safe and effective method for controlling bleeding in dermatologic surgery.
- This delivery route offers particular benefit for patients on anticoagulant therapy, improving hemostatic control.
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