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Autoimmune myelofibrosis: a rare haematological involvement in systemic lupus erythematosus
Nabil Belfeki1, Gopinath Shankarasivam1, Damienne Declerck2
1Internal Medicine and Infectious Disease Department, Centre Hospitalier Sud Ile de France, Melun, France.
Abstract:
Autoimmune myelofibrosis is a distinct clinicopathological entity that occurs with autoimmune disorders. We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of systemic lupus erythematosus, Sjogren's syndrome and antiphospholipid antibodies syndrome. Bone marrow biopsy showed decreased global cells and an increase of reticulin fibres on argentic coloration, consistent with myelofibrosis. The JAK2 V617, Myeloproliferative leukemia (MPL) and calreticulin mutations were negative. The patient's condition improved after treatment with hydroxychloroquine, vitamin K antagonists and prednisone.
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