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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Advanced squamous lung cancer: therapeutic options, future directions, unmet needs and results of a monocentric
Valentina Bertaglia1,1, Stefania Vallone2,2, Maria Vittoria Pacchiana1,1
1Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.
Abstract:
Lung cancer is the leading cause of cancer-related deaths in worldwide, and NSCLC represents around 85% of all lung cancers. Squamous cell lung cancer (SqCLC) is the second most common subtype and it is challenging to treat. New options have been discovered but progresses are still limited for the lack of 'druggable' mutations. Specific resources for SqCLC are limited and this condition affects treatment and outcomes. This paper describes available and emerging therapeutic options and resources that may help patients to face their disease. We have also performed a monocentric survey collecting information about smoking habit and sense of guilty and analyzed the possibility for patients to find helpful sources for their disease. The results suggest that more materials focused on SqCLC are still needed.
Insights
Squamous cell lung cancer (SqCLC) treatment is challenging due to limited targeted therapies and resources. More SqCLC-specific patient materials are needed to improve care and outcomes for this common lung cancer subtype.
Area of Science:
- Oncology
- Thoracic Surgery
- Pulmonology
Background:
- Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, with squamous cell lung cancer (SqCLC) being the second most prevalent subtype.
- SqCLC presents significant treatment challenges due to a lack of 'druggable' mutations and limited specific resources.
- Existing therapeutic advancements for lung cancer have shown limited progress for SqCLC patients.
Purpose of the Study:
- To review available and emerging therapeutic options and resources for SqCLC patients.
- To assess patient-reported information on smoking habits and guilt.
- To evaluate the accessibility of helpful resources for SqCLC patients.
Main Methods:
- Literature review of current and novel therapeutic strategies for SqCLC.
- Monocentric survey collecting data on patient smoking habits and sense of guilt.
- Analysis of patient-reported resource availability and utilization.
Main Results:
- SqCLC treatment remains difficult, with limited targeted therapy options.
- A survey indicated a need for better patient support and resources.
- Patients' access to and awareness of SqCLC-specific information is insufficient.
Conclusions:
- There is a critical need for enhanced therapeutic strategies and 'druggable' targets in SqCLC.
- Development of SqCLC-specific educational and support materials is essential.
- Improving resource accessibility can positively impact treatment adherence and patient outcomes.
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