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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Rapidly Progressive, Isolated Subretinal Leukemic Relapse: A Case Report.

Thomas B Gillette¹, Michelle T Cabrera², Katherine Tarlock³

¹Clinical and Translational Research, Seattle Children's Hospital, University of Washington.

Ocular Oncology and Pathology

|January 16, 2019

Summary

This summary is machine-generated.

A rapidly progressing subretinal infiltrate in a pediatric patient with acute lymphoblastic leukemia (ALL) was diagnosed using ultrasound-guided fine needle aspiration (FNA). Prompt diagnosis is crucial for effective treatment and vision preservation.

Keywords:

Enucleation Fine-needle aspiration Fine-needle aspiration choroidal biopsy Leukemia Ocular relapse Optic nerve infiltration Serous retinal detachment Subretinal infiltrate

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Area of Science:

Ophthalmology
Pediatric Oncology
Hematology

Background:

Pediatric acute lymphoblastic leukemia (ALL) can relapse in various sites.
Ocular involvement in leukemia relapse is rare but serious.
Early detection of relapse is critical for patient outcomes.

Purpose of the Study:

To report a case of relapsed pediatric ALL presenting as a subretinal infiltrate.
To highlight the diagnostic utility of ultrasound-guided fine needle aspiration (FNA) in such cases.
To emphasize the importance of prompt diagnosis for managing ocular leukemia.

Main Methods:

Retrospective chart review of a pediatric patient with T-cell ALL.
Utilized B-scan ultrasonography to assess retinal changes.
Performed ultrasound-guided fine needle aspiration (FNA) for diagnosis.
Histopathological examination of the enucleated eye.

Main Results:

A 17-year-old patient in remission developed acute glaucoma and retinal detachment.
Central nervous system relapse of T-cell ALL was confirmed.
Ultrasound-guided FNA revealed leukemic infiltrate in the subretinal mass.
Histopathology confirmed extensive leukemic infiltration in the eye.

Conclusions:

Retinal detachment in leukemia patients warrants investigation for relapse.
Ultrasound-guided FNA is valuable for diagnosing subretinal infiltrates when other methods are inconclusive.
Rapidly progressing subretinal infiltrates require prompt diagnosis and tailored therapy to preserve vision.