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Related Experiment Video

Updated: Jan 30, 2026

Generation of Topically Transgenic Rats by In utero Electroporation and In vivo Bioluminescence Screening
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Elevated Transaminases with Topical Diclofenac: A Case Report.

Amanda M Daniels, Lawrence M Gibbs, Christopher M Herndon

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    Summary

    Topical diclofenac gel can cause drug-induced liver injury (DILI), a rare side effect. In a case study, elevated liver enzymes in a 79-year-old female normalized after stopping the topical nonsteroidal anti-inflammatory drug (NSAID).

    Keywords:
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    Area of Science:

    • Hepatology
    • Pharmacology
    • Clinical Toxicology

    Background:

    • Drug-induced liver injury (DILI) is a known risk associated with nonsteroidal anti-inflammatory drugs (NSAIDs).
    • Oral diclofenac has a higher reported incidence of DILI compared to other NSAIDs, necessitating monitoring.
    • Hepatotoxicity from NSAIDs requires careful clinical evaluation of signs and symptoms.

    Observation:

    • A case report details a 79-year-old female experiencing elevated liver transaminases.
    • The patient was using topical diclofenac 1% gel.
    • Liver transaminase levels normalized after the discontinuation of topical diclofenac.

    Findings:

    • The temporal relationship between topical diclofenac use and elevated liver transaminases was established.
    • A causality assessment using a validated instrument assigned a
    • definite
    • rating for drug-induced liver injury.
    • This case highlights a potential hepatotoxic risk associated with topical diclofenac formulations.

    Implications:

    • The findings suggest that topical NSAIDs, including diclofenac gel, may pose a risk of DILI.
    • Further research is needed to understand the incidence and risk factors for DILI from topical NSAIDs.
    • Clinical guidelines may need to be updated to address the potential hepatotoxicity of topical NSAIDs.