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Related Experiment Videos

[Preoperative subjective anxiety. Double blind study using oxazepam].

W Kröll1, U V Wisiak, W F List

  • 1Universitätsklinik für Anaesthesiologie, Graz.

Der Anaesthesist
|December 1, 1988
PubMed
Summary

Oxazepam effectively reduces preoperative anxiety in female patients undergoing breast surgery. This benzodiazepine offers significant anxiolysis compared to placebo, improving patient comfort before procedures.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Psychiatry

Background:

  • Preoperative anxiety and memory of unpleasant experiences are key concerns in surgical care.
  • Effective premedication aims to reduce anxiety, provide sedation, and induce amnesia.
  • Benzodiazepines are commonly used for their anxiolytic and sedative properties.

Purpose of the Study:

  • To evaluate the anxiolytic effects of oral oxazepam as a premedication in female patients undergoing breast lesion surgery.
  • To compare the efficacy of oxazepam versus placebo in reducing preoperative anxiety.

Main Methods:

  • A prospective, randomized, double-blind study involving 60 female patients (ASA class I and II).
  • Patients received either 30 mg oral oxazepam or placebo 90 minutes before induction.

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  • Preoperative anxiety was assessed using the Mannheim protocol for subjective feeling (MESB) and the State-Trait Anxiety Inventory (STAI).

    • Main Results:

    • Both oxazepam and placebo groups exhibited high preoperative anxiety levels.
    • Oxazepam administration led to a significant decrease in anxiety intensity as measured by both MESB and STAI.
    • The Mannheim protocol for subjective feeling was considered a more effective tool for assessing perioperative anxiety than the STAI.

    Conclusions:

    • Oxazepam is an effective oral premedicant for achieving anxiolysis in the immediate perioperative period.
    • The study highlights the utility of oxazepam in managing preoperative anxiety for patients undergoing breast surgery.
    • The Mannheim protocol for subjective feeling demonstrates superior utility in evaluating perioperative anxiety compared to the STAI.