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Published on: May 25, 2022
N-methyl-bacillithiol, a Novel Thiol from Anaerobic Bacteria
Gerald L Newton1, Mamta Rawat2
1Division of Biological Sciences, University of California, San Diego, San Diego, California, USA.
Abstract:
J. Hiras, S. V. Sharma, V. Raman, R. A. J. Tinson, et al. (mBio 9:e01603-18, 2018, https://doi.org/10.1128/mBio.01603-18) report on the identification of a novel thiol, N-methyl-bacillithiol (N-Me-BSH), in the green sulfur bacterium Chlorobium tepidum In N-methyl-bacillithiol, the amine of the cysteine is methylated by a novel S-adenosylmethioneine transferase designated N-methyl-bacillithiol synthase A (NmbA). The Hiras et al. study is significant because it is the first report of the presence of N-Me-BSH in anaerobic bacteria.
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