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Published on: January 31, 2025
Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study
Meghan M Holst1, Michael D Wirth, Anna Mnatsakanova
1Department of Epidemiology and Biostatistics, Arnold School of Public Health (Mr Holst, Dr Wirth, Dr Burch); Cancer Prevention and Control Program (Dr Wirth, Dr Burch); College of Nursing (Dr Wirth), University of South Carolina; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Ms Mnatsakanova, Dr Charles, Ms Tinney-Zara, Dr Fekedulegn, Dr Andrew, Dr Hartley); WJB Dorn VA Medical Center (Dr Burch), Columbia, South Carolina; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University of Buffalo, The State University of New York, Buffalo, New York (Dr Violanti).
Objective:
To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.
Methods:
A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.
Results:
Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m versus the day shift.
Conclusions:
Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
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