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Perspectives on Neuroscience
Published on: July 31, 2007
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How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives
1Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, Maryland.
Summary
Homeostasis, a core concept in physiology, is viewed differently by integrative physiology and systems biology. This perspective proposes a future reconciliation of these approaches, incorporating evolution and adaptiveness.
Area of Science:
- Integrative physiology and systems biology.
- Autonomic neuroscience.
Background:
- Homeostasis is a foundational principle in integrative physiology, focusing on goals and purpose.
- Systems biology, data-driven and omics-focused, emphasizes mechanisms over goals.
- A philosophical divide exists between these two epistemologies regarding the nature of biological function and explanation.
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