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Updated: Jan 30, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Ni-Catalyzed Reductive Liebeskind-Srogl Alkylation of Heterocycles
Yuanhong Ma1, Jose Cammarata1, Josep Cornella1
1Max-Planck-Institut für Kohlenforschung , Kaiser-Wilhelm-Platz 1 , Mülheim an der Ruhr , 45470 , Germany.
Abstract:
Herein we present a Ni-catalyzed alkylation of C-SMe with alkyl bromides for the decoration of heterocyclic frameworks. The protocol, reminiscent to the Liebeskind-Srogl coupling, makes use of simple C(sp2)-SMe to be engaged in a reductive coupling. The reaction is suitable for a preponderance of highly valuable heterocyclic motifs. In addition to cyclic bromides, noncyclic alkyl bromides are well accommodated with exquisite levels of retention over isomerization. The protocol is scalable and permits orthogonal couplings in the presence of other functionalization handles.
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