Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.2K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.2K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.2K
pH Regulation in Cells01:28

pH Regulation in Cells

7.6K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.6K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

7.1K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.1K
Epigenetic Regulation01:46

Epigenetic Regulation

33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dendritic Cell Heterogeneity Tailored to Their Function.

Immunological reviews·2026
Same author

A Human Lymph node-on-a-Chip for Personalized Evaluation of Vaccine Immunogenicity.

Research square·2026
Same author

Transcription factor Etv3 controls the tolerogenic function of dendritic cells.

Science (New York, N.Y.)·2026
Same author

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells.

Immunity·2026
Same author

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.

Science immunology·2026
Same author

DNA origami vaccines program antigen-focused germinal centers.

Science (New York, N.Y.)·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
Same journal

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

Immunity·2026
Same journal

The transcription factor Eomes drives a stemness program in CD4<sup>+</sup> T cells that promotes anti-tumor immunity in response to immunotherapy.

Immunity·2026
Same journal

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection.

Immunity·2026
Same journal

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.

Immunity·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

11.5K

Plasmacytoid Dendritic Cells: Development, Regulation, and Function.

Boris Reizis1

  • 1Department of Pathology and Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

Immunity
|January 17, 2019
PubMed
Summary
This summary is machine-generated.

Plasmacytoid dendritic cells (pDCs) are key immune sentinels detecting nucleic acids and producing type I interferon. This review covers pDC biology, their role in immunity and disease, and future research directions for therapeutic applications.

Keywords:
Plasmacytoid dendritic cells (pDCs) are innate immune sentinels that play important roles in immunity to infection and autoimmunity. This review by Boris Reizis highlights recent progress and emerging areas of interest in pDC biology as well as translational applications

More Related Videos

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

13.0K
In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System
08:18

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System

Published on: November 23, 2015

8.9K

Related Experiment Videos

Last Updated: Jan 30, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

11.5K
Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

13.0K
In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System
08:18

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System

Published on: November 23, 2015

8.9K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Plasmacytoid dendritic cells (pDCs) are critical immune cells.
  • pDCs detect pathogen nucleic acids and produce type I interferon.
  • pDCs play roles in antiviral immunity and immune pathologies like autoimmune diseases and cancer.

Purpose of the Study:

  • To review current knowledge on pDC biology.
  • To discuss the role of pDCs in antiviral responses and immune pathology.
  • To identify knowledge gaps and future research directions for pDC function.

Main Methods:

  • Literature review of pDC research.
  • Analysis of transcriptional regulation in pDCs.
  • Examination of pDC heterogeneity and function.

Main Results:

  • pDCs are essential for rapid type I interferon production.
  • pDC function is implicated in autoimmune diseases, immunodeficiency, and cancer.
  • The molecular basis of pDC interferon production requires further elucidation.

Conclusions:

  • Understanding pDC biology is crucial for immune response and disease.
  • Further research into pDC regulation can lead to translational applications.
  • Targeting pDC function holds therapeutic potential for various diseases.