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Updated: Aug 1, 2026
09:31
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
Published on: April 8, 2015
Structure and function of the bone marrow and hematopoiesis.
G L Gulati1, J K Ashton, B H Hyun
1University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway.
Hematology/Oncology Clinics of North America
|December 1, 1988
Summary
Bone marrow is a vital tissue for blood cell production (hematopoiesis) and immune responses. Its regulation involves cell interactions and growth factors, with potential therapeutic applications.
Area of Science:
- Hematology
- Immunology
- Cell Biology
Background:
- Bone marrow is a complex tissue essential for hematopoiesis and immune functions.
- It comprises stromal cells and hematopoietic cells, supporting blood cell development.
- Bone marrow lacks lymphatic vessels but is richly innervated and vascularized.
Purpose of the Study:
- To describe the structure and function of bone marrow.
- To elucidate the regulatory mechanisms of hematopoiesis.
- To highlight the potential of hematopoietic growth factors in therapy.
Main Methods:
- Literature review and synthesis of existing knowledge on bone marrow biology.
- Analysis of cellular components and their interactions.
- Discussion of regulatory factors and their characterization.
Main Results:
- Bone marrow supports hematopoiesis through regulated proliferation and differentiation of stem cells.
- Hematopoiesis is controlled by cell-cell interactions and humoral factors.
- Isolated and characterized regulators of hematopoiesis show therapeutic promise.
Conclusions:
- Bone marrow is a dynamic organ with intricate regulatory mechanisms for blood cell production.
- Understanding these mechanisms is crucial for developing novel therapies.
- Recombinant growth factors derived from bone marrow research are entering clinical trials.
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