Elastography detected solid organ stiffness increased in patients with acromegaly
Mehmet Bankir1, Hilmi Erdem Sumbul1, Ayse Selcan Koc2
1Department of Internal Medicine.
Medicine
|January 18, 2019
Summary
Solid organ stiffness (SOS) increases in active acromegaly patients. Insulin growth factor-1 (IGF-1) levels are independently linked to this increased stiffness, suggesting elastography as a valuable diagnostic tool.
Area of Science:
- Endocrinology and Medical Imaging
Background:
- Acromegaly is a disorder caused by excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1).
- Elastography, a non-invasive ultrasound technique, measures solid organ stiffness (SOS), but its application in acromegaly is unexplored.
Purpose of the Study:
- To investigate changes in SOS in patients with acromegaly.
- To identify factors associated with SOS in acromegaly patients.
Main Methods:
- A comparative study involving 40 acromegaly patients and 40 healthy controls.
- Elastography was used to measure SOS in the liver, kidneys, and thyroid gland.
- Patients were categorized into control, remission, and active disease groups.
Main Results:
- Acromegaly patients, particularly those with active disease, exhibited significantly increased liver, kidney, and thyroid stiffness compared to controls and those in remission.
- Elevated Insulin growth factor-1 (IGF-1) levels were observed in active acromegaly patients.
- IGF-1 levels were identified as an independent determinant of SOS in acromegaly patients.
Conclusions:
- Increased SOS is a significant finding in active acromegaly.
- Elastography, combined with IGF-1 monitoring, can be a valuable addition to routine ultrasound examinations for acromegaly patients.
- Routine elastography screening is recommended for acromegaly patients, especially those with active disease.
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