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Transabdominal versus transcervical chorionic villus sampling: a randomized trial.

B Brambati1, A Oldrini, A Lanzani

  • 1Unità di Medicina Perinatale, Prima Clinica ostetrica e ginecologica, Università di Milano, Italy.

Human Reproduction (Oxford, England)
|August 1, 1988
PubMed
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Chorionic villus sampling (CVS) safety is under evaluation. This study compares transcervical and transabdominal CVS, finding both highly successful but with differing sample characteristics and procedural deviations.

Area of Science:

  • Medical research
  • Obstetrics and Gynecology

Background:

  • Chorionic villus sampling (CVS) is an important prenatal diagnostic technique.
  • Its safety and comparative efficacy between transcervical and transabdominal approaches require further investigation through randomized trials.

Purpose of the Study:

  • To compare the efficiency and risks of transcervical versus transabdominal chorionic villus sampling.
  • To evaluate preliminary outcomes from an ongoing randomized trial.

Main Methods:

  • A preliminary analysis of 639 consecutive cases from a randomized trial comparing transcervical and transabdominal CVS.
  • Data collected on sampling success, tissue sample characteristics, and procedural deviations.

Main Results:

  • Both transcervical and transabdominal CVS achieved over 99% sampling success.

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  • Transabdominal CVS yielded lighter tissue samples, but very light specimens (<10 mg) were equally distributed.
  • Repeat insertions were more frequent with the transcervical route, and deviations from the allocated procedure occurred in ~10% of cases, more often with the transcervical method.

    • Conclusions:

    • Both CVS techniques demonstrate high success rates.
    • Differences exist in sample weight and procedural requirements, suggesting potential considerations for technique selection based on clinical factors.