The Life Course Health Development Model: A theoretical research framework for paediatric delirium
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Updated: Jan 30, 2026

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Published on: July 12, 2024
1The Ohio State University College of Nursing, Columbus, Ohio.
Insights
The Life Course Health Development Model offers a framework to understand how paediatric delirium impacts a child's long-term health trajectory. This model can guide future research and clinical practice changes for critically ill children.
Area of Science:
- Pediatric critical care research
- Health development models
- Neuroscience of critical illness
Background:
- Pediatric intensive care unit (PICU) delirium is linked to worse outcomes, including longer ventilation, hospital stays, and mortality.
- Nurses play a crucial role in identifying, preventing, and managing pediatric delirium at the bedside.
- Understanding the long-term effects of pediatric delirium is vital for advancing nursing research and practice.
Purpose of the Study:
- To apply and critique the Life Course Health Development Model (LCHDM) for pediatric delirium research.
- To establish a framework for future research on pediatric delirium using the LCHDM.
- To stimulate discussion and practice change regarding pediatric delirium.
Main Methods:
- A critical literature review was conducted, applying the LCHDM to pediatric delirium.
- The seven core principles of the LCHDM were examined in the context of pediatric delirium.
- The model's utility for guiding future research and practice change was critiqued.
Main Results:
- The LCHDM framework highlights how critical illness-induced stress can lead to neurological changes contributing to delirium.
- Application of the LCHDM reveals potential lifelong impacts of pediatric delirium on a child's health trajectory.
- Gaps in current understanding and future research directions for pediatric delirium were identified.
Conclusions:
- The LCHDM illustrates the pathway from critical illness stress to delirium and impaired life trajectory in children.
- Emphasizing lifelong consequences of pediatric delirium can drive research and practice advancements.
- The LCHDM provides a valuable lens for understanding and addressing pediatric delirium.
Aims And Objectives:
To create a framework for future research through application and critique of the Life Course Health Development Model to the phenomenon of paediatric delirium.
Background:
Delirium in the paediatric intensive care unit is associated with increased duration of mechanical ventilation, length of stay and mortality. Nurses are uniquely positioned at the bedside to identify, prevent and treat delirium. An understanding of the potential long-term consequences of paediatric delirium is necessary to provide impetus for nursing research and practice change. The Life Course Health Development Model is a valuable tool when considering the multiple mechanisms and processes through which the experience of delirium could affect a child's life trajectory.
Design:
Critical review of the literature through application and critique of the Life Course Health Development Model in the context of paediatric delirium. Gaps in the current understanding of paediatric delirium, as well as future directions for research and practice, are discussed.
Methods:
The seven core principles of the model are considered in the context of paediatric delirium. Each of the principles has the potential to further understanding of paediatric delirium and identify areas for future inquiry. This discussion leads to a critique of the ability of the model to lead future research and practice change.
Conclusions:
The Life Course Health Development Model depicts a process in which the acute and severe stress of critical illness leads to maladaptive neurologic changes that contribute to the development of delirium and impair a child's life trajectory.
Relevance To Clinical Practice:
By emphasising the potential lifelong consequences for critically ill children who experience delirium, this application of the Life Course Health Development Model will stimulate discussion, research and practice change among paediatric clinicians and researchers.
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