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Skull's Photoacoustic Attenuation and Dispersion Modeling with Deterministic Ray-Tracing: Towards Real-Time
Leila Mohammadi1, Hamid Behnam2, Jahan Tavakkoli3,4
1Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran 1477893855, Iran. lemoelec@gmail.com.
Sensors (Basel, Switzerland)
|January 19, 2019
Summary
This study introduces a fast ray-tracing model to simulate skull effects in photoacoustic imaging. The new method accurately predicts wave distortions, enabling better transcranial brain imaging.
Area of Science:
- Biomedical Optics
- Acoustic Imaging
- Computational Modeling
Background:
- Transcranial photoacoustic imaging is hindered by skull-induced wave distortions.
- Existing finite-element methods are computationally slow for detailed 3D skull modeling.
Purpose of the Study:
- To develop a fast and accurate computational framework for modeling ultrasound wave propagation through the skull.
- To improve the simulation of skull distorting effects for enhanced transcranial photoacoustic brain imaging.
Main Methods:
- Developed a deterministic ray-tracing framework for simulating wave propagation.
- Incorporated multilayered media, frequency-dependent attenuation, dispersion, reflection, refraction, and mode conversion.
- Validated the framework against numerical phantoms, k-Wave simulations, and ex vivo experimental data.
Main Results:
- The ray-tracing framework significantly accelerates skull modeling compared to finite-element methods.
- Accurate simulation of amplitude attenuation, signal broadening, and time shift caused by the skull.
- Validated findings through numerical, analytical, and experimental comparisons.
Conclusions:
- The proposed ray-tracing method offers a fast and accurate solution for modeling skull effects in photoacoustic imaging.
- This framework can facilitate advancements in transcranial photoacoustic brain imaging by improving signal quantification and image reconstruction.