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Pleural dedifferentiated liposarcoma: A case report
Susumu Matsukuma1,2, Yoshiro Oshika3, Yoshitaka Utsumi1
1Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan.
Molecular and Clinical Oncology
|January 19, 2019
Summary
This case report details a rare pleural dedifferentiated liposarcoma in a 45-year-old man. Aggressive local growth led to rapid mortality, highlighting the poor prognosis of this liposarcoma subtype.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Pleural liposarcoma is an exceptionally rare malignancy.
- Dedifferentiated liposarcoma subtype is associated with aggressive behavior and poor prognosis.
- Accurate diagnosis and understanding of its behavior are crucial for patient management.
Purpose of the Study:
- To report a rare case of pleural dedifferentiated liposarcoma.
- To describe the clinical presentation, diagnostic findings, and treatment of this rare tumor.
- To review the literature regarding the prognosis of pleural dedifferentiated liposarcoma.
Main Methods:
- Case presentation of a 45-year-old male with chest pain and pleural tumor.
- Diagnostic imaging (CT scan) and histopathological examination of biopsy and surgical specimens.
- Immunohistochemical analysis (MDM2, S-100 protein) for tumor characterization.
- Review of relevant medical literature.
Main Results:
- A 10-cm pleural tumor was initially identified, later growing to 35 cm.
- Histopathology revealed undifferentiated sarcomatous features with lipoblasts positive for MDM2 and S-100.
- The patient underwent palliative treatment but experienced rapid tumor regrowth and metastasis.
- Autopsy confirmed pleural dedifferentiated liposarcoma with metastases to adrenal glands and vertebrae, and a concurrent lung adenocarcinoma.
Conclusions:
- Pleural dedifferentiated liposarcoma is an aggressive malignancy with a poor prognosis.
- Local tumor aggressiveness was the direct cause of mortality in this patient.
- The dedifferentiated subtype is a significant indicator of poor outcomes in pleural liposarcoma.
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