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Published on: April 1, 2019
Toll-like receptor 4 promoter polymorphisms in a familial mediterranean fever patient with asymptomatic bacteriuria
Shinichiro Kawamoto1, Ryota Masutani2,3, Keiji Kurata4
1Department of Transfusion Medicine and Cell Therapy Kobe University Hospital Hyogo Japan.
Abstract:
A periodic fever, due to inherited inflammatory disorders, can be misdiagnosed as a common infection, when a possible pathogen is detected from a patient. TLR4 SNPs that are responsible for asymptomatic bacteriuria might disturb the pathophysiology of familial Mediterranean fever without MEFV mutations.
Insights
Periodic fever, an inherited inflammatory disorder, can be mistaken for infection. Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNPs) may affect familial Mediterranean fever in patients lacking MEFV mutations.
Area of Science:
- Genetics
- Immunology
- Infectious Diseases
Background:
- Periodic fever syndromes are inherited inflammatory disorders.
- Misdiagnosis as common infection occurs, especially when pathogens are detected.
- Familial Mediterranean fever (FMF) is a primary autoinflammatory disease.
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