Toll-like receptor 4 promoter polymorphisms in a familial mediterranean fever patient with asymptomatic bacteriuria

Shinichiro Kawamoto1, Ryota Masutani2,3, Keiji Kurata4

  • 1Department of Transfusion Medicine and Cell Therapy Kobe University Hospital Hyogo Japan.

Clinical Case Reports
|January 19, 2019
PubMed

Insights

Periodic fever, an inherited inflammatory disorder, can be mistaken for infection. Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNPs) may affect familial Mediterranean fever in patients lacking MEFV mutations.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Periodic fever syndromes are inherited inflammatory disorders.
  • Misdiagnosis as common infection occurs, especially when pathogens are detected.
  • Familial Mediterranean fever (FMF) is a primary autoinflammatory disease.

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